- 26-Jun-10 "Crossroads Guitar Festival" - Toyota Park, Bridgeview IL
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- Bill Murray Introduction with Eric Clapton
- Promise Land (Sonny Landreth with Eric Clapton)
- Z Rider (Sonny Landreth)
- Traveling Shoes (Robert Randolph and the Family Band)
- Going Down (Joe Bonamassa and Pino Daniele with Robert Randolph)
- Bill Murray introduces Robert Cray
- Killing Floor (Robert Cray, Jimmie Vaughn and Hubert Sumlin)
- Six Stings Down (Jimmie Vaughn, Robert Cray and Hubert Sumlin)
- Bill Murray introduces ZZ Top
- Waiting For the Bus (ZZ Top)
- Jesus Just Left Chicago (ZZ Top)
- Gypsy Blood (Doyle Bramhall II)
- In My Time Of Dying (Doyle Bramhall II)
- Bright Lights (Gary Clark Jr)
- Long Road Home (Sheryl Crow with Derek Trucks, Susan Tedeschi, Doyle Bramhall II and Gary Clark Jr)
- Our Love Is Fading (Sheryl Crow with Eric Clapton, Doyle Bramhall II and Gary Clark Jr)
- Blackwaterside (Bert Jansch)
- Mississippi Blues (Stefan Grossman with Keb Mo)
- Roll 'N' Tumble (Stefan Grossman with Keb Mo)
- Bill Murray introduces Vince Gill
- One More Last Chance (Vince Gill, Keb Mo, James Burton, Earl Klugh, Albert Lee)
- ]Mystery Train (Vince Gill, James Burton, Albert Lee, Keb Mo, Earl Klugh)
- Lay Down Sally (Vince Gill, Keb Mo, Albert Lee, James Burton, Earl Klugh and Sheryl Crow)
- Angelina (Earl Klugh)
- Vonetta (Earl Klugh)
- Bill Murray introduces John Mayer
- Who Did You Think I Was (John Mayer Trio)
- Ain't No Sunshine (John Mayer Trio)
- Bill Murray introduces Derek Trucks
- Midnight In Harlem (Derek Trucks and Susan Tedeschi Band)
- Coming Home (Derek Trucks and Susan Tedeschi Band featuring Warren Haynes)
- Soulshine (Warren Haynes)
- Don't Keep Me Wondering (David Hidalgo and Cesar Rosas featuring Derek Trucks)
- Space Captain (Derek Trucks and Susan Tedeschi Band featuring Warren Haynes, David Hidalgo, Cesar Rosas, Chris Stainton)
- Bill Murray introduces Buddy Guy, Jonny Lang and Ronnie Wood
- Five Long Years (Buddy Guy with Jonny Lang and Ronnie Wood)
- Miss You (Buddy Guy with Jonny Lang and Ronnie Wood)
- Bill Murray introduces Jeff Beck
- Hammerhead (Jeff Beck)
- Nessun Dorma (Jeff Beck)
- Bill Murray introduces Eric Clapton
- Crossroads (Eric Clapton)
- Hands of the Saints (Eric Clapton and Citizen Cope)
- I Shot The Sheriff (Eric Clapton)
- Shake Your Money Maker (Eric Clapton and Jeff Beck)
- Had To Cry Today (Eric Clapton and Steve Winwood)
- Voodoo Chile (Eric Clapton and Steve Winwood)
- Dear Mr. Fantasy (Eric Clapton and Steve Winwood)
- Bill Murray introduces BB King
- The Thrill Is Gone (Finale: Eric Clapton, BB King, Robert Cray, Jimmie Vaughn, Joe Bonamassa, and others)
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